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DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions

Regulation of transcription occurs in a cell type specific manner orchestrated by epigenetic mechanisms including DNA methylation. Methylation changes may also play a key role in lineage specification during stem cell differentiation. To further our understanding of epigenetic regulation in chondroc...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Barter, Matt J., Bui, Catherine, Cheung, Kathleen, Falk, Julia, Gómez, Rodolfo, Skelton, Andrew J., Elliott, Hannah R., Reynard, Louise N., Young, David A.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6981252/
https://ncbi.nlm.nih.gov/pubmed/31980739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58093-5
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