Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype

Vascular senescence is thought to play a crucial role in an ageing-associated decline of organ functions; however, whether vascular senescence is causally implicated in age-related disease remains unclear. Here we show that endothelial cell (EC) senescence induces metabolic disorders through the sen...

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Udgivet i:Nat Commun
Main Authors: Barinda, Agian Jeffilano, Ikeda, Koji, Nugroho, Dhite Bayu, Wardhana, Donytra Arby, Sasaki, Naoto, Honda, Sakiko, Urata, Ryota, Matoba, Satoaki, Hirata, Ken-ichi, Emoto, Noriaki
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6981212/
https://ncbi.nlm.nih.gov/pubmed/31980643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14387-w
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