PTH induces bone loss via microbial-dependent expansion of intestinal TNF(+) T cells and Th17 cells

Bone loss is a frequent but not universal complication of hyperparathyroidism. Using antibiotic-treated or germ-free mice, we show that parathyroid hormone (PTH) only caused bone loss in mice whose microbiota was enriched by the Th17 cell-inducing taxa segmented filamentous bacteria (SFB). SFB(+) mi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Yu, Mingcan, Malik Tyagi, Abdul, Li, Jau-Yi, Adams, Jonathan, Denning, Timothy L., Weitzmann, M. Neale, Jones, Rheinallt M., Pacifici, Roberto
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6981196/
https://ncbi.nlm.nih.gov/pubmed/31980603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14148-4
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