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PTH induces bone loss via microbial-dependent expansion of intestinal TNF(+) T cells and Th17 cells
Bone loss is a frequent but not universal complication of hyperparathyroidism. Using antibiotic-treated or germ-free mice, we show that parathyroid hormone (PTH) only caused bone loss in mice whose microbiota was enriched by the Th17 cell-inducing taxa segmented filamentous bacteria (SFB). SFB(+) mi...
Shranjeno v:
| izdano v: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6981196/ https://ncbi.nlm.nih.gov/pubmed/31980603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14148-4 |
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