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Genotype-fitness maps of EGFR-mutant lung adenocarcinoma chart the evolutionary landscape of resistance for combination therapy optimization
Cancer evolution poses a central obstacle to cure, as resistant clones expand under therapeutic selection pressures. Genome sequencing in relapsed disease can nominate genomic alterations conferring resistance, but sample collection lags behind, limiting therapeutic innovation. Genome-wide screens o...
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| Publicado no: | Cell Syst |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6981068/ https://ncbi.nlm.nih.gov/pubmed/31668800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2019.10.002 |
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