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Beclin 1 promotes endosome recruitment of hepatocyte growth factor tyrosine kinase substrate (HRS) to suppress tumor proliferation

Beclin 1 has non-autophagic functions that include its ability to regulate endocytic receptor trafficking. However, the contribution of this function to tumor suppression is poorly understood. Here, we provide in vivo evidence that Beclin 1 suppresses tumor proliferation by regulating the endocytic...

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Foilsithe in:Cancer Res
Main Authors: Matthew-Onabanjo, Asia N., Janusis, Jenny, Mercado-Matos, Jose, Carlisle, Anne E., Kim, Dohoon, Levine, Fayola, Cruz-Gordillo, Peter, Richards, Ryan, Lee, Michael J., Shaw, Leslie M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980665/
https://ncbi.nlm.nih.gov/pubmed/31744816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1555
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