Beclin 1 promotes endosome recruitment of hepatocyte growth factor tyrosine kinase substrate (HRS) to suppress tumor proliferation

Beclin 1 has non-autophagic functions that include its ability to regulate endocytic receptor trafficking. However, the contribution of this function to tumor suppression is poorly understood. Here, we provide in vivo evidence that Beclin 1 suppresses tumor proliferation by regulating the endocytic...

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Vydáno v:Cancer Res
Hlavní autoři: Matthew-Onabanjo, Asia N., Janusis, Jenny, Mercado-Matos, Jose, Carlisle, Anne E., Kim, Dohoon, Levine, Fayola, Cruz-Gordillo, Peter, Richards, Ryan, Lee, Michael J., Shaw, Leslie M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980665/
https://ncbi.nlm.nih.gov/pubmed/31744816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1555
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