A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib

The combined influence of oncogenic drivers, genomic instability, and/or DNA damage repair deficiencies increases replication stress in cancer. Cells with high replication stress rely on the upregulation of checkpoints like those governed by CHK1 for survival. Previous studies of the CHK1 inhibitor...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Blosser, Wayne D., Dempsey, Jack A., McNulty, Ann M., Rao, Xi, Ebert, Philip J., Lowery, Caitlin D., Iversen, Philip W., Webster, Yue Wang, Donoho, Gregory P., Gong, Xueqian, Merzoug, Farhana F., Buchanan, Sean, Boehnke, Karsten, Yu, Chunping, You, Xin Tian, Beckmann, Richard P., Wu, Wenjuan, McNeely, Samuel C., Lin, Aimee Bence, Martinez, Ricardo
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980627/
https://ncbi.nlm.nih.gov/pubmed/32076484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27400
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