Mesenchymal stem cell-derived exosomes ameliorate cardiomyocyte apoptosis in hypoxic conditions through microRNA144 by targeting the PTEN/AKT pathway

BACKGROUND: A growing body of evidence suggests that stem cell-derived exosomal microRNAs (miRNAs) could be a promising cardioprotective therapy in the context of hypoxic conditions. The present study aims to explore how miRNA-144 (miR-144), a miRNA contained in bone marrow mesenchymal stem cell (MS...

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Publicat a:Stem Cell Res Ther
Autors principals: Wen, Zhuzhi, Mai, Zun, Zhu, Xiaolin, Wu, Tao, Chen, Yangxin, Geng, Dengfeng, Wang, Jingfeng
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6979357/
https://ncbi.nlm.nih.gov/pubmed/31973741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-020-1563-8
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