GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

[Image: see text] Ferroptosis is an iron-dependent form of regulated cell death linking iron, lipid, and glutathione levels to degenerative processes and tumor suppression. By performing a genome-wide activation screen, we identified a cohort of genes antagonizing ferroptotic cell death, including G...

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Vydáno v:ACS Cent Sci
Hlavní autoři: Kraft, Vanessa A. N., Bezjian, Carla T., Pfeiffer, Susanne, Ringelstetter, Larissa, Müller, Constanze, Zandkarimi, Fereshteh, Merl-Pham, Juliane, Bao, Xuanwen, Anastasov, Natasa, Kössl, Johanna, Brandner, Stefanie, Daniels, Jacob D., Schmitt-Kopplin, Philippe, Hauck, Stefanie M., Stockwell, Brent R., Hadian, Kamyar, Schick, Joel A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2019
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6978838/
https://ncbi.nlm.nih.gov/pubmed/31989025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.9b01063
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