Programmable Bivalent Peptide–DNA Locks for pH-Based Control of Antibody Activity

[Image: see text] The ability to control antibody activity by pH has important applications in diagnostics, therapeutic antibody targeting, and antibody-guided imaging. Here, we report the rational design of bivalent peptide–DNA ligands that allow pH-dependent control of antibody activity. Our strat...

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Bibliographic Details
Published in:ACS Cent Sci
Main Authors: Engelen, Wouter, Zhu, Kwankwan, Subedi, Nikita, Idili, Andrea, Ricci, Francesco, Tel, Jurjen, Merkx, Maarten
Format: Artigo
Language:Inglês
Published: American Chemical Society 2019
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6978833/
https://ncbi.nlm.nih.gov/pubmed/31989023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.9b00964
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