A Novel G Protein–Biased Agonist at the δ Opioid Receptor with Analgesic Efficacy in Models of Chronic Pain

Agonists at the δ opioid receptor are known to be potent antihyperalgesics in chronic pain models and effective in models of anxiety and depression. However, some δ opioid agonists have proconvulsant properties while tolerance to the therapeutic effects can develop. Previous evidence indicates that...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Conibear, Alexandra E., Asghar, Junaid, Hill, Rob, Henderson, Graeme, Borbely, Eva, Tekus, Valeria, Helyes, Zsuzsanna, Palandri, Josephine, Bailey, Chris, Starke, Ingemar, von Mentzer, Bengt, Kendall, David, Kelly, Eamonn
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2020
Assuntos:
Drug Discovery and Translational Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6978697/
https://ncbi.nlm.nih.gov/pubmed/31594792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.258640
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