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Limitations of Animal Studies for Predicting Toxicity in Clinical Trials: Is it Time to Rethink Our Current Approach?

Animal testing is used in pharmaceutical and industrial research to predict human toxicity, and yet analysis suggests that animal models are poor predictors of drug safety in humans. The cost of animal research is high—in dollars, delays in drug approval, and in the loss of potentially beneficial dr...

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Vydáno v:JACC Basic Transl Sci
Hlavní autor: Van Norman, Gail A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6978558/
https://ncbi.nlm.nih.gov/pubmed/31998852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2019.10.008
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