Frataxin deficiency induces lipid accumulation and affects thermogenesis in brown adipose tissue

Decreased expression of mitochondrial frataxin (FXN) causes Friedreich’s ataxia (FRDA), a neurodegenerative disease with type 2 diabetes (T2D) as severe comorbidity. Brown adipose tissue (BAT) is a mitochondria-enriched and anti-diabetic tissue that turns excess energy into heat to maintain metaboli...

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Gepubliceerd in:Cell Death Dis
Hoofdauteurs: Turchi, Riccardo, Tortolici, Flavia, Guidobaldi, Giulio, Iacovelli, Federico, Falconi, Mattia, Rufini, Stefano, Faraonio, Raffaella, Casagrande, Viviana, Federici, Massimo, De Angelis, Lorenzo, Carotti, Simone, Francesconi, Maria, Zingariello, Maria, Morini, Sergio, Bernardini, Roberta, Mattei, Maurizio, Rosa, Piergiorgio La, Piemonte, Fiorella, Lettieri-Barbato, Daniele, Aquilano, Katia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6978516/
https://ncbi.nlm.nih.gov/pubmed/31974344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2253-2
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