p53 controls genomic stability and temporal differentiation of human neural stem cells and affects neural organization in human brain organoids

In this study, we take advantage of human induced pluripotent stem (iPS) cell-derived neural stem cells and brain organoids to study the role of p53 during human brain development. We knocked down (KD) p53 in human neuroepithelial stem (NES) cells derived from iPS cells. Upon p53KD, NES cells rapidl...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Marin Navarro, Ana, Pronk, Robin Johan, van der Geest, Astrid Tjitske, Oliynyk, Ganna, Nordgren, Ann, Arsenian-Henriksson, Marie, Falk, Anna, Wilhelm, Margareta
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6978389/
https://ncbi.nlm.nih.gov/pubmed/31974372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-2208-7
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