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Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma
Ferroptosis is a newly defined form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides. Erastin, the ferroptosis activator, binds to voltage-dependent anion channels VDAC2 and VDCA3, but treatment with erastin can result in the degradation of the channel...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6978386/ https://ncbi.nlm.nih.gov/pubmed/31974380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14324-x |
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