Silencing of microRNA‐494 inhibits the neurotoxic Th1 shift via regulating HDAC2‐STAT4 cascade in ischaemic stroke

BACKGROUND AND PURPOSE: T helper cell 1 (Th1)‐skewed neurotoxicity contributes to the poor outcome of stroke in rodents. Here, we have elucidated the mechanism of the Th1/Th2 shift in acute ischaemic stroke (AIS) patients at hyperacute phase and have looked for a miRNA‐based therapeutic target. EXPE...

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Detalles Bibliográficos
Publicado en:Br J Pharmacol
Autores principales: Zhao, Haiping, Li, Guangwen, Wang, Rongliang, Tao, Zhen, Ma, Qingfeng, Zhang, Sijia, Han, Ziping, Yan, Feng, Li, Fangfang, Liu, Ping, Ma, Shubei, Ji, Xunming, Luo, Yumin
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6976789/
https://ncbi.nlm.nih.gov/pubmed/31465536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14852
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