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Pol μ ribonucleotide insertion opposite 8-oxodG facilitates the ligation of premutagenic DNA repair intermediate

DNA polymerase (pol) μ primarily inserts ribonucleotides into a single-nucleotide gapped DNA intermediate, and the ligation step plays a critical role in the joining of noncomplementary DNA ends during nonhomologous end joining (NHEJ) for the repair of double-strand breaks (DSBs) caused by reactive...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Rep
Glavni avtor: Çağlayan, Melike
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6976671/
https://ncbi.nlm.nih.gov/pubmed/31969622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57886-y
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