Cervical carcinomas that overexpress human trophoblast cell-surface marker (Trop-2) are highly sensitive to the antibody-drug conjugate sacituzumab govitecan

Human trophoblast cell-surface marker (Trop-2) is a surface glycoprotein originally identified in human placental tissue and subsequently found to be highly expressed by various types of human epithelial solid tumors. We investigated the efficacy of sacituzumab govitecan, an antibody-drug conjugate...

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Pubblicato in:Sci Rep
Autori principali: Zeybek, Burak, Manzano, Aranzazu, Bianchi, Anna, Bonazzoli, Elena, Bellone, Stefania, Buza, Natalia, Hui, Pei, Lopez, Salvatore, Perrone, Emanuele, Manara, Paola, Zammataro, Luca, Altwerger, Gary, Han, Chanhee, Tymon-Rosario, Joan, Menderes, Gulden, Ratner, Elena, Silasi, Dan-Arin, Huang, Gloria S., Azodi, Masoud, Schwartz, Peter E., Santin, Alessandro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6976591/
https://ncbi.nlm.nih.gov/pubmed/31969666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58009-3
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