Association Between Preanalytical Factors and Tumor Mutational Burden Estimated by Next‐Generation Sequencing‐Based Multiplex Gene Panel Assay

BACKGROUND. Tumor mutational burden (TMB) measured via next‐generation sequencing (NGS)‐based gene panel is a promising biomarker for response to immune checkpoint inhibitors (ICIs) in solid tumors. However, little is known about the preanalytical factors that can affect the TMB score. MATERIALS AND...

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Vydáno v:Oncologist
Hlavní autoři: Quy, Pham Nguyen, Kanai, Masashi, Fukuyama, Keita, Kou, Tadayuki, Kondo, Tomohiro, Yamamoto, Yoshihiro, Matsubara, Junichi, Hiroshima, Akinori, Mochizuki, Hiroaki, Sakuma, Tomohiro, Kamada, Mayumi, Nakatsui, Masahiko, Eso, Yuji, Seno, Hiroshi, Masui, Toshihiko, Takaori, Kyoichi, Minamiguchi, Sachiko, Matsumoto, Shigemi, Muto, Manabu
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Inc. 2019
Témata:
Immuno‐Oncology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6975932/
https://ncbi.nlm.nih.gov/pubmed/31186376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2018-0587
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