Association Between Preanalytical Factors and Tumor Mutational Burden Estimated by Next‐Generation Sequencing‐Based Multiplex Gene Panel Assay

BACKGROUND. Tumor mutational burden (TMB) measured via next‐generation sequencing (NGS)‐based gene panel is a promising biomarker for response to immune checkpoint inhibitors (ICIs) in solid tumors. However, little is known about the preanalytical factors that can affect the TMB score. MATERIALS AND...

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Détails bibliographiques
Publié dans:Oncologist
Auteurs principaux: Quy, Pham Nguyen, Kanai, Masashi, Fukuyama, Keita, Kou, Tadayuki, Kondo, Tomohiro, Yamamoto, Yoshihiro, Matsubara, Junichi, Hiroshima, Akinori, Mochizuki, Hiroaki, Sakuma, Tomohiro, Kamada, Mayumi, Nakatsui, Masahiko, Eso, Yuji, Seno, Hiroshi, Masui, Toshihiko, Takaori, Kyoichi, Minamiguchi, Sachiko, Matsumoto, Shigemi, Muto, Manabu
Format: Artigo
Langue:Inglês
Publié: John Wiley & Sons, Inc. 2019
Sujets:
Immuno‐Oncology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6975932/
https://ncbi.nlm.nih.gov/pubmed/31186376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2018-0587
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