Association Between Preanalytical Factors and Tumor Mutational Burden Estimated by Next‐Generation Sequencing‐Based Multiplex Gene Panel Assay

BACKGROUND. Tumor mutational burden (TMB) measured via next‐generation sequencing (NGS)‐based gene panel is a promising biomarker for response to immune checkpoint inhibitors (ICIs) in solid tumors. However, little is known about the preanalytical factors that can affect the TMB score. MATERIALS AND...

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Detalhes bibliográficos
Publicado no:Oncologist
Main Authors: Quy, Pham Nguyen, Kanai, Masashi, Fukuyama, Keita, Kou, Tadayuki, Kondo, Tomohiro, Yamamoto, Yoshihiro, Matsubara, Junichi, Hiroshima, Akinori, Mochizuki, Hiroaki, Sakuma, Tomohiro, Kamada, Mayumi, Nakatsui, Masahiko, Eso, Yuji, Seno, Hiroshi, Masui, Toshihiko, Takaori, Kyoichi, Minamiguchi, Sachiko, Matsumoto, Shigemi, Muto, Manabu
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2019
Assuntos:
Immuno‐Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6975932/
https://ncbi.nlm.nih.gov/pubmed/31186376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2018-0587
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