Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways

The cullin-RING ligases (CRLs) form the major family of E3 ubiquitin ligases. The prototypic CRLs in yeast, called SCF enzymes, employ a single E2 enzyme, Cdc34, to build poly-ubiquitin chains required for degradation. In contrast, six different human E2 and E3 enzyme activities, including Cdc34 ort...

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Vydáno v:eLife
Hlavní autoři: Hill, Spencer, Reichermeier, Kurt, Scott, Daniel C, Samentar, Lorena, Coulombe-Huntington, Jasmin, Izzi, Luisa, Tang, Xiaojing, Ibarra, Rebeca, Bertomeu, Thierry, Moradian, Annie, Sweredoski, Michael J, Caberoy, Nora, Schulman, Brenda A, Sicheri, Frank, Tyers, Mike, Kleiger, Gary
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2019
Témata:
Biochemistry and Chemical Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6975927/
https://ncbi.nlm.nih.gov/pubmed/31868589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51163
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