NKp46-expressing human gut-resident intraepithelial Vδ1 T cell subpopulation exhibits high antitumor activity against colorectal cancer

γδ T cells account for a large fraction of human intestinal intraepithelial lymphocytes (IELs) endowed with potent antitumor activities. However, little is known about their origin, phenotype, and clinical relevance in colorectal cancer (CRC). To determine γδ IEL gut specificity, homing, and functio...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Mikulak, Joanna, Oriolo, Ferdinando, Bruni, Elena, Roberto, Alessandra, Colombo, Federico S., Villa, Anna, Bosticardo, Marita, Bortolomai, Ileana, Lo Presti, Elena, Meraviglia, Serena, Dieli, Francesco, Vetrano, Stefania, Danese, Silvio, Della Bella, Silvia, Carvello, Michele M., Sacchi, Matteo, Cugini, Giovanni, Colombo, Giovanni, Klinger, Marco, Spaggiari, Paola, Roncalli, Massimo, Prinz, Immo, Ravens, Sarina, di Lorenzo, Biagio, Marcenaro, Emanuela, Silva-Santos, Bruno, Spinelli, Antonino, Mavilio, Domenico
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6975269/
https://ncbi.nlm.nih.gov/pubmed/31689241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.125884
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