Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production

Chinese hamster ovary (CHO) cell expression systems have been exquisitely developed for the production of recombinant biotherapeutics (e.g. standard monoclonal antibodies, mAbs) and are able to generate efficacious, multi-domain proteins with human-like post translational modifications at high conce...

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Bibliografski detalji
Izdano u:Metab Eng
Glavni autori: Budge, James D., Knight, Tanya J., Povey, Jane, Roobol, Joanne, Brown, Ian R., Singh, Gurdeep, Dean, Andrew, Turner, Sarah, Jaques, Colin M., Young, Robert J., Racher, Andrew J., Smales, C. Mark
Format: Artigo
Jezik:Inglês
Izdano: Academic Press 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6975165/
https://ncbi.nlm.nih.gov/pubmed/31805379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymben.2019.11.007
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