Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production

Chinese hamster ovary (CHO) cell expression systems have been exquisitely developed for the production of recombinant biotherapeutics (e.g. standard monoclonal antibodies, mAbs) and are able to generate efficacious, multi-domain proteins with human-like post translational modifications at high conce...

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Vydáno v:Metab Eng
Hlavní autoři: Budge, James D., Knight, Tanya J., Povey, Jane, Roobol, Joanne, Brown, Ian R., Singh, Gurdeep, Dean, Andrew, Turner, Sarah, Jaques, Colin M., Young, Robert J., Racher, Andrew J., Smales, C. Mark
Médium: Artigo
Jazyk:Inglês
Vydáno: Academic Press 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6975165/
https://ncbi.nlm.nih.gov/pubmed/31805379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymben.2019.11.007
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