A characterization of cis- and trans-heritability of RNA-Seq-based gene expression

Insights into individual differences in gene expression and its heritability (h(2)) can help in understanding pathways from DNA to phenotype. We estimated the heritability of gene expression of 52,844 genes measured in whole blood in the largest twin RNA-Seq sample to date (1497 individuals includin...

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Vydáno v:Eur J Hum Genet
Hlavní autoři: Ouwens, Klaasjan G., Jansen, Rick, Nivard, Michel G., van Dongen, Jenny, Frieser, Maia J., Hottenga, Jouke-Jan, Arindrarto, Wibowo, Claringbould, Annique, van Iterson, Maarten, Mei, Hailiang, Franke, Lude, Heijmans, Bastiaan T., A. C. ’t Hoen, Peter, van Meurs, Joyce, Brooks, Andrew I., Penninx, Brenda W. J. H., Boomsma, Dorret I.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6974598/
https://ncbi.nlm.nih.gov/pubmed/31558840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41431-019-0511-5
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