Immune Suppression Mediated by STAT4 Deficiency Promotes Lymphatic Metastasis in HNSCC

Head and neck squamous cell carcinoma (HNSCC) is a prevalent form of cancer with 5-years survival rates around 57%, and metastasis is a leading cause of mortality. Host-derived immunological factors that affect HNSCC tumor development and metastasis are not completely understood. We investigated the...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Anderson, Kelvin, Ryan, Nathan, Volpedo, Greta, Varikuti, Sanjay, Satoskar, Abhay R., Oghumu, Steve
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6974475/
https://ncbi.nlm.nih.gov/pubmed/32010142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.03095
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