Resistance to ectromelia virus infection requires cGAS in bone marrow-derived cells which can be bypassed with cGAMP therapy

Cells sensing infection produce Type I interferons (IFN-I) to stimulate Interferon Stimulated Genes (ISGs) that confer resistance to viruses. During lympho-hematogenous spread of the mouse pathogen ectromelia virus (ECTV), the adaptor STING and the transcription factor IRF7 are required for IFN-I an...

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Bibliographic Details
Published in:PLoS Pathog
Main Authors: Wong, Eric B., Montoya, Brian, Ferez, Maria, Stotesbury, Colby, Sigal, Luis J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6974301/
https://ncbi.nlm.nih.gov/pubmed/31877196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008239
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