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Covalent‐Allosteric Inhibitors to Achieve Akt Isoform‐Selectivity
Isoforms of protein kinase Akt are involved in essential processes including cell proliferation, survival, and metabolism. However, their individual roles in health and disease have not been thoroughly evaluated. Thus, there is an urgent need for perturbation studies, preferably mediated by highly s...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6972997/ https://ncbi.nlm.nih.gov/pubmed/31584233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201909857 |
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