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Distinct roles of the three Akt isoforms in lactogenic differentiation and involution
The three Akt isoforms differ in their ability to transduce oncogenic signals initiated by the Neu and PyMT oncogenes in mammary epithelia. As a result, ablation of Akt1 inhibits and ablation of Akt2 accelerates mammary tumor development by both oncogenes, while ablation of Akt3 is phenotypically al...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2871282/ https://ncbi.nlm.nih.gov/pubmed/18561256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21518 |
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