Investigating Chaperonin-Containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis

Chaperonin-containing TCP-1 (CCT or TRiC) is a multi-subunit complex that folds many of the proteins essential for cancer development. CCT is expressed in diverse cancers and could be an ideal therapeutic target if not for the fact that the complex is encoded by eight distinct genes, complicating th...

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Published in:Sci Rep
Main Authors: Showalter, Anne E., Martini, Ana C., Nierenberg, Daniel, Hosang, Kristen, Fahmi, Naima Ahmed, Gopalan, Priya, Khaled, Amr S., Zhang, Wei, Khaled, Annette R.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6972895/
https://ncbi.nlm.nih.gov/pubmed/31964905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57602-w
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