Xanthine oxidase inhibition attenuates insulin resistance and diet-induced steatohepatitis in mice

Hyperuricemia drives the development of nonalcoholic fatty liver disease (NAFLD). Pharmacological inhibition of xanthine oxidase (XO), a rate-limiting enzyme for uric acid (UA) production, has been demonstrated to improve hepatic steatosis in diet-induced obese mice. However, it remains unclear whet...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Nishikawa, Tomoki, Nagata, Naoto, Shimakami, Tetsuro, Shirakura, Takashi, Matsui, Chieko, Ni, Yinhua, Zhuge, Fen, Xu, Liang, Chen, Guanliang, Nagashimada, Mayumi, Yamashita, Taro, Sakai, Yoshio, Yamashita, Tatsuya, Mizukoshi, Eishiro, Honda, Masao, Kaneko, Shuichi, Ota, Tsuguhito
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6972756/
https://ncbi.nlm.nih.gov/pubmed/31965018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57784-3
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