SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice

Sodium-glucose cotransporter (SGLT) 2 inhibitors increase urinary glucose excretion (UGE), leading to blood glucose reductions and weight loss. However, the impacts of SGLT2 inhibition on energy homeostasis and obesity-induced insulin resistance are less well known. Here, we show that empagliflozin,...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Xu, Liang, Nagata, Naoto, Nagashimada, Mayumi, Zhuge, Fen, Ni, Yinhua, Chen, Guanliang, Mayoux, Eric, Kaneko, Shuichi, Ota, Tsuguhito
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478253/
https://ncbi.nlm.nih.gov/pubmed/28579299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.05.028
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