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Cycling hypoxia promotes a pro-inflammatory phenotype in macrophages via JNK/p65 signaling pathway

Cycling hypoxia (cyH), also called intermittent hypoxia, occurs in solid tumors and affects different cell types in the tumor microenvironment and in particular the tumor-associated macrophages (TAMs). As cyH and TAMs both favor tumor progression, we investigated whether cyH could drive the pro-tumo...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Delprat, Victor, Tellier, Céline, Demazy, Catherine, Raes, Martine, Feron, Olivier, Michiels, Carine
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6972721/
https://ncbi.nlm.nih.gov/pubmed/31964911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57677-5
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