A Light‐Activated Acyl Carrier Protein “Trap” for Intermediate Capture in Type II Iterative Polyketide Biocatalysis

A discrete acyl carrier protein (ACP) bearing a photolabile nonhydrolysable carba(dethia) malonyl pantetheine cofactor was chemoenzymatically prepared and utilised for the trapping of biosynthetic polyketide intermediates following light activation. From the in vitro assembly of the polyketides SEK4...

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Vydáno v:Chemistry
Hlavní autoři: Kilgour, Samantha L., Kilgour, David P. A., Prasongpholchai, Panward, O'Connor, Peter B., Tosin, Manuela
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6972679/
https://ncbi.nlm.nih.gov/pubmed/31596972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201903662
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