Deoxyguanosine is a TLR7 agonist

Toll‐like receptor 7 (TLR7) is an innate immune sensor for single‐strand RNA (ssRNA). Recent structural analysis revealed that TLR7 has an additional binding site for nucleosides such as guanosine, and is activated when both guanosine and ssRNA bind. The nucleoside binding site also accommodates imi...

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Bibliographic Details
Published in:Eur J Immunol
Main Authors: Davenne, Tamara, Bridgeman, Anne, Rigby, Rachel E., Rehwinkel, Jan
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
Subjects:
Innate immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6972671/
https://ncbi.nlm.nih.gov/pubmed/31608988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201948151
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