A first Japanese case of neuroendocrine prostate cancer accompanied by lung and brain metastasis with somatic and germline BRCA2 mutation

Germline mutations and copy number changes in DNA damage repair (DDR) genes such as BRCA2 are associated with aggressive forms of prostate cancer (PCa). Although the prevalence of BRCA2 variants in PCa is increasing in Japan, the genomic and biological implications in Japanese patients are unclear....

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Detalhes bibliográficos
Publicado no:Pathol Int
Main Authors: Kosaka, Takeo, Hongo, Hiroshi, Aimono, Eriko, Matsumoto, Kazuhiro, Hayashida, Tetsu, Mikami, Shuji, Nishihara, Hiroshi, Oya, Mototsugu
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Case Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6972566/
https://ncbi.nlm.nih.gov/pubmed/31631483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pin.12860
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