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Clinical implications of the oncometabolite succinate in SDHx‐mutation carriers
Succinate dehydrogenase (SDH) mutations lead to the accumulation of succinate, which acts as an oncometabolite. Germline SDHx mutations predispose to paraganglioma (PGL) and pheochromocytoma (PCC), as well as to renal cell carcinoma and gastro‐intestinal stromal tumors. The SDHx genes were the first...
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| 發表在: | Clin Genet |
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| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Blackwell Publishing Ltd
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6972524/ https://ncbi.nlm.nih.gov/pubmed/30977114 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cge.13553 |
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