Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC

OBJECTIVE: The MHC region harbors the strongest loci for latent autoimmune diabetes in adults (LADA); however, the strength of association is likely attenuated compared with that for childhood-onset type 1 diabetes. In this study, we recapitulate independent effects in the MHC class I region in a po...

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Detalles Bibliográficos
Publicado en:Diabetes Care
Main Authors: Mishra, Rajashree, Åkerlund, Mikael, Cousminer, Diana L., Ahlqvist, Emma, Bradfield, Jonathan P., Chesi, Alessandra, Hodge, Kenyaita M., Guy, Vanessa C., Brillon, David J., Pratley, Richard E., Rickels, Michael R., Vella, Adrian, Ovalle, Fernando, Harris, Ronald I., Melander, Olle, Varvel, Stephen, Hakonarson, Hakon, Froguel, Phillippe, Lonsdale, John T., Mauricio, Didac, Schloot, Nanette C., Khunti, Kamlesh, Greenbaum, Carla J., Yderstræde, Knud B., Tuomi, Tiinamaija, Voight, Benjamin F., Schwartz, Stanley, Boehm, Bernhard O., Groop, Leif, Leslie, Richard David, Grant, Struan F.A.
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2020
Assuntos:
Pathophysiology/Complications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6971787/
https://ncbi.nlm.nih.gov/pubmed/31843946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/dc19-0986
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