Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC

OBJECTIVE: The MHC region harbors the strongest loci for latent autoimmune diabetes in adults (LADA); however, the strength of association is likely attenuated compared with that for childhood-onset type 1 diabetes. In this study, we recapitulate independent effects in the MHC class I region in a po...

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Detalhes bibliográficos
Publicado no:Diabetes Care
Main Authors: Mishra, Rajashree, Åkerlund, Mikael, Cousminer, Diana L., Ahlqvist, Emma, Bradfield, Jonathan P., Chesi, Alessandra, Hodge, Kenyaita M., Guy, Vanessa C., Brillon, David J., Pratley, Richard E., Rickels, Michael R., Vella, Adrian, Ovalle, Fernando, Harris, Ronald I., Melander, Olle, Varvel, Stephen, Hakonarson, Hakon, Froguel, Phillippe, Lonsdale, John T., Mauricio, Didac, Schloot, Nanette C., Khunti, Kamlesh, Greenbaum, Carla J., Yderstræde, Knud B., Tuomi, Tiinamaija, Voight, Benjamin F., Schwartz, Stanley, Boehm, Bernhard O., Groop, Leif, Leslie, Richard David, Grant, Struan F.A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2020
Assuntos:
Pathophysiology/Complications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6971787/
https://ncbi.nlm.nih.gov/pubmed/31843946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/dc19-0986
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