Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC

OBJECTIVE: The MHC region harbors the strongest loci for latent autoimmune diabetes in adults (LADA); however, the strength of association is likely attenuated compared with that for childhood-onset type 1 diabetes. In this study, we recapitulate independent effects in the MHC class I region in a po...

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Vydáno v:Diabetes Care
Hlavní autoři: Mishra, Rajashree, Åkerlund, Mikael, Cousminer, Diana L., Ahlqvist, Emma, Bradfield, Jonathan P., Chesi, Alessandra, Hodge, Kenyaita M., Guy, Vanessa C., Brillon, David J., Pratley, Richard E., Rickels, Michael R., Vella, Adrian, Ovalle, Fernando, Harris, Ronald I., Melander, Olle, Varvel, Stephen, Hakonarson, Hakon, Froguel, Phillippe, Lonsdale, John T., Mauricio, Didac, Schloot, Nanette C., Khunti, Kamlesh, Greenbaum, Carla J., Yderstræde, Knud B., Tuomi, Tiinamaija, Voight, Benjamin F., Schwartz, Stanley, Boehm, Bernhard O., Groop, Leif, Leslie, Richard David, Grant, Struan F.A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2020
Témata:
Pathophysiology/Complications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6971787/
https://ncbi.nlm.nih.gov/pubmed/31843946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/dc19-0986
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