Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer

Emergence of an aggressive androgen receptor (AR)-independent neuroendocrine prostate cancer (NEPC) after androgen-deprivation therapy (ADT) is well-known. Nevertheless, the majority of advanced-stage prostate cancer patients, including those with SPINK1-positive subtype, are treated with AR-antagon...

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Vydáno v:Nat Commun
Hlavní autoři: Tiwari, Ritika, Manzar, Nishat, Bhatia, Vipul, Yadav, Anjali, Nengroo, Mushtaq A., Datta, Dipak, Carskadon, Shannon, Gupta, Nilesh, Sigouros, Michael, Khani, Francesca, Poutanen, Matti, Zoubeidi, Amina, Beltran, Himisha, Palanisamy, Nallasivam, Ateeq, Bushra
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6971084/
https://ncbi.nlm.nih.gov/pubmed/31959826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14184-0
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