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Epigenetic silencing of miRNA-338-5p and miRNA-421 drives SPINK1-positive prostate cancer

PURPOSE: Serine Peptidase Inhibitor, Kazal type-1 (SPINK1) overexpression defines the second most recurrent and aggressive prostate cancer (PCa) subtype. However, the underlying molecular mechanism and pathobiology of SPINK1 in PCa remains largely unknown. EXPERIMENTAL DESIGN: MicroRNA-prediction to...

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Detalles Bibliográficos
Publicado en:Clin Cancer Res
Main Authors: Bhatia, Vipul, Yadav, Anjali, Tiwari, Ritika, Nigam, Shivansh, Goel, Sakshi, Carskadon, Shannon, Gupta, Nilesh, Goel, Apul, Palanisamy, Nallasivam, Ateeq, Bushra
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6517268/
https://ncbi.nlm.nih.gov/pubmed/30587549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-3230
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