Intercellular Adhesion Molecule-1 (ICAM-1) and ICAM-2 Differentially Contribute to Peripheral Activation and CNS Entry of Autoaggressive Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis

In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), myelin-specific T cells are activated in the periphery and differentiate in T helper (Th) 1 and Th17 effector cells, which cross the blood-brain barrier (BBB) to reach the central nervous system (CNS), wh...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Haghayegh Jahromi, Neda, Marchetti, Luca, Moalli, Federica, Duc, Donovan, Basso, Camilla, Tardent, Heidi, Kaba, Elisa, Deutsch, Urban, Pot, Caroline, Sallusto, Federica, Stein, Jens V., Engelhardt, Britta
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6970977/
https://ncbi.nlm.nih.gov/pubmed/31993059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.03056
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