Enhancing Betulinic Acid Dissolution Rate and Improving Antitumor Activity via Nanosuspension Constructed by Anti-Solvent Technique

PURPOSE: The aim of this study was to prepare and evaluate betulinic acid nanosuspension (BA-NS) for new drug delivery to enhance its solubility and in vitro anti-tumor activity. METHODS: BA-NS was formulated by an anti-solvent precipitation method using the Box-Behnken design (BBD). Particle size (...

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Bibliographic Details
Published in:Drug Des Devel Ther
Main Authors: Li, Shuqi, Zhang, Jie, Fang, Yuqi, Yi, Jun, Lu, Zhufen, Chen, Yanzhong, Guo, Bohong
Format: Artigo
Language:Inglês
Published: Dove 2020
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6970624/
https://ncbi.nlm.nih.gov/pubmed/32021108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S233851
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