The human coronavirus HCoV-229E S-protein structure and receptor binding

The coronavirus S-protein mediates receptor binding and fusion of the viral and host cell membranes. In HCoV-229E, its receptor binding domain (RBD) shows extensive sequence variation but how S-protein function is maintained is not understood. Reported are the X-ray crystal structures of Class III-V...

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Udgivet i:eLife
Main Authors: Li, Zhijie, Tomlinson, Aidan CA, Wong, Alan HM, Zhou, Dongxia, Desforges, Marc, Talbot, Pierre J, Benlekbir, Samir, Rubinstein, John L, Rini, James M
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2019
Fag:
Biochemistry and Chemical Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6970540/
https://ncbi.nlm.nih.gov/pubmed/31650956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51230
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