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Synthetic Evidence of the Amadori-Type Alkylation of Biogenic Amines by the Neurotoxic Metabolite Dopegal

[Image: see text] The neurotransmitter metabolite 3,4-dihydroxy-phenylglycolaldehyde (dopegal) damages neurons and the myocardium by protein cross-linking, resulting in conglomerations and cell death. We investigated this process on a synthetic scale, leading to the discovery of an Amadori-type rear...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Org Chem
Prif Awduron: Wanner, Martin J., Zuidinga, Ed, Tromp, Dorette S., Vilím, Jan, Jørgensen, Steen Ingemann, van Maarseveen, Jan H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2019
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6970265/
https://ncbi.nlm.nih.gov/pubmed/31841007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.9b01948
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