Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer

Reprogramming the tumor microenvironment to increase immune-mediated responses is currently of intense interest. Patients with immune-infiltrated “hot” tumors demonstrate higher treatment response rates and improved survival. However, only the minority of tumors are hot, and a limited proportion of...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Newman, Jenna H., Chesson, C. Brent, Herzog, Nora L., Bommareddy, Praveen K., Aspromonte, Salvatore M., Pepe, Russell, Estupinian, Ricardo, Aboelatta, Mones M., Buddhadev, Stuti, Tarabichi, Saeed, Lee, Michael, Li, Shengguo, Medina, Daniel J., Giurini, Eileena F., Gupta, Kajal H., Guevara-Aleman, Gabriel, Rossi, Marco, Nowicki, Christina, Abed, Abdulkareem, Goldufsky, Josef W., Broucek, Joseph R., Redondo, Raquel E., Rotter, David, Jhawar, Sachin R., Wang, Shang-Jui, Kohlhapp, Frederick J., Kaufman, Howard L., Thomas, Paul G., Gupta, Vineet, Kuzel, Timothy M., Reiser, Jochen, Paras, Joyce, Kane, Michael P., Singer, Eric A., Malhotra, Jyoti, Denzin, Lisa K., Sant’Angelo, Derek B., Rabson, Arnold B., Lee, Leonard Y., Lasfar, Ahmed, Langenfeld, John, Schenkel, Jason M., Fidler, Mary Jo, Ruiz, Emily S., Marzo, Amanda L., Rudra, Jai S., Silk, Ann W., Zloza, Andrew
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969546/
https://ncbi.nlm.nih.gov/pubmed/31888983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904022116
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