Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer

Reprogramming the tumor microenvironment to increase immune-mediated responses is currently of intense interest. Patients with immune-infiltrated “hot” tumors demonstrate higher treatment response rates and improved survival. However, only the minority of tumors are hot, and a limited proportion of...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Newman, Jenna H., Chesson, C. Brent, Herzog, Nora L., Bommareddy, Praveen K., Aspromonte, Salvatore M., Pepe, Russell, Estupinian, Ricardo, Aboelatta, Mones M., Buddhadev, Stuti, Tarabichi, Saeed, Lee, Michael, Li, Shengguo, Medina, Daniel J., Giurini, Eileena F., Gupta, Kajal H., Guevara-Aleman, Gabriel, Rossi, Marco, Nowicki, Christina, Abed, Abdulkareem, Goldufsky, Josef W., Broucek, Joseph R., Redondo, Raquel E., Rotter, David, Jhawar, Sachin R., Wang, Shang-Jui, Kohlhapp, Frederick J., Kaufman, Howard L., Thomas, Paul G., Gupta, Vineet, Kuzel, Timothy M., Reiser, Jochen, Paras, Joyce, Kane, Michael P., Singer, Eric A., Malhotra, Jyoti, Denzin, Lisa K., Sant’Angelo, Derek B., Rabson, Arnold B., Lee, Leonard Y., Lasfar, Ahmed, Langenfeld, John, Schenkel, Jason M., Fidler, Mary Jo, Ruiz, Emily S., Marzo, Amanda L., Rudra, Jai S., Silk, Ann W., Zloza, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969546/
https://ncbi.nlm.nih.gov/pubmed/31888983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904022116
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