Structure of the cell-binding component of the Clostridium difficile binary toxin reveals a di-heptamer macromolecular assembly

Targeting Clostridium difficile infection is challenging because treatment options are limited, and high recurrence rates are common. One reason for this is that hypervirulent C. difficile strains often have a binary toxin termed the C. difficile toxin, in addition to the enterotoxins TsdA and TsdB....

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Xu, Xingjian, Godoy-Ruiz, Raquel, Adipietro, Kaylin A., Peralta, Christopher, Ben-Hail, Danya, Varney, Kristen M., Cook, Mary E., Roth, Braden M., Wilder, Paul T., Cleveland, Thomas, Grishaev, Alexander, Neu, Heather M., Michel, Sarah L. J., Yu, Wenbo, Beckett, Dorothy, Rustandi, Richard R., Lancaster, Catherine, Loughney, John W., Kristopeit, Adam, Christanti, Sianny, Olson, Jessica W., MacKerell, Alexander D., des Georges, Amedee, Pozharski, Edwin, Weber, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969506/
https://ncbi.nlm.nih.gov/pubmed/31896582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1919490117
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