Pre-treatment with the viral Toll-like receptor 3 agonist poly(I:C) modulates innate immunity and protects neutropenic mice infected intracerebrally with Escherichia coli

BACKGROUND: Individuals with impaired immunity are more susceptible to infections than immunocompetent subjects. No vaccines are currently available to induce protection against E. coli meningoencephalitis. This study evaluated the potential of poly(I:C) pre-treatment to induce trained immunity. Pol...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Ribes, Sandra, Arcilla, Christa, Ott, Martina, Schütze, Sandra, Hanisch, Uwe-Karsten, Nessler, Stefan, Nau, Roland
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969464/
https://ncbi.nlm.nih.gov/pubmed/31952519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-1700-4
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