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The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD
Pyrazinamide has been a mainstay in the multidrug regimens used to treat tuberculosis. It is active against the persistent, non-replicating mycobacteria responsible for the protracted therapy required to cure tuberculosis. Pyrazinamide is a pro-drug that is converted into pyrazinoic acid (POA) by py...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6969166/ https://ncbi.nlm.nih.gov/pubmed/31953389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14238-3 |
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